Drug intelligence / Profile preview

[68Ga]Ga-XY-PSMA-ICG

Development stage
Unknown
Lead developer
Central South University
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
01

Overview

[68Ga]Ga-XY-PSMA-ICG: sourced facts only. name: "PSMA-positive xenograft models were established to verify the PSMA-targeting ability of XY-PSMA-ICG and [68Ga]Ga-XY-PSMA-ICG via fluorescence and PET imaging, and first-in-human studies were conducted to assess the safety, biodistribution, and PSMA imaging potential of [68Ga]Ga-XY-PSMA-ICG." [PMID:42101325]; target: "PSMA-positive xenograft models were established to verify the PSMA-targeting ability of XY-PSMA-ICG and [68Ga]Ga-XY-PSMA-ICG via fluorescence and PET imaging, and first-in-human studies were conducted to assess the safety, biodistribution, and PSMA imaging potential of [68Ga]Ga-XY-PSMA-ICG." [PMID:42101325]; developer: "Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China." [PMID:42101325]; modality: "In this study, a novel PET/fluorescence dual-modality probe [68Ga]Ga-XY-PSMA-ICG was designed and synthesized, and its affinity, specificity, biodistribution, pharmacokinetics, and radiation dosimetry were evaluated in vitro and in vivo." [PMID:42101325]

02

Targets

PSMA (Prostate-specific membrane antigen)

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